Role of Altered Fractionation & Chemoradiation in Head and Neck Cancer
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چکیده
Dividing a dose into a number of fractions spares normal tissues because of repair of SLD between dose fractions and repopulation of cells if the overall time is sufficiently long. At the same time dividing a dose into a number of fractions increases the damage to the tumor because of reoxygenation and reassortment of cells into radiosensitive phases of the cell cycles between dose fractions. The advantages of prolongation of treatment are to spare early reactions and to allow adequate reoxygenation in tumour. Excessive prolongation allows surviving tumor cells to proliferate during treatment.
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